ELISA Recombinant Tumor necrosis factor receptor superfamily member 12A protein(TNFRSF12A),partial (Active)

Quantity:100µg. Research Areas:Cancer Uniprot NO.:Q9NP84 Uniprot Entry Name:TNR12_ Gene Names:TNFRSF12A,FN14 Species:Homo sapiens () Source:E.Coli Expression Region:28-80aa Sequence:EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP Protein Description:Partial Tag Info:Tag-Free Mol. Weight:5.6 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by inhibiting TWEAK- dependent proliferation of umbilical vein endothelial cells (HUVEC) is less than 30 ng/mL, corresponding to a specific activity of ? 3.3 × 104 IU/mg, in the presence of 15 ng/mL of rHuTWEAK. Purity:>95% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, TweakR, CD antigen CD266, Relevance:Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modµLate cellµLar adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}. PubMed ID:10751351; 15489334; 11728344; 19241374 Function:Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modµLate cellµLar adhesion to matrix proteins. Involvement in disease: SubcellµLar Location:Membrane, Single-pass type I membrane protein Protein Families: Tissue Specificity:Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. Paythway: HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:18152 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=355899 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:51330 STRING Database Link:https://string-db.org/network/9606.ENSP00000326737 OMIM Database Link:https://www.omim.org/entry/605914605914605914