AMD 95 Potent LPA1 receptor

AMD 95 Potent LPA1 receptor 

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AMD-070

A3173-5 5 mg
EUR 235
Description: AMD-070 is a selective and oral bioavailable antagonist of chemokine receptor CXCR4 with IC50 value of 13 nM [1].CXCR4 is a G-protein-coupled receptor that plays important roles in tumor development.

AMD-070

A3173-5.1 10 mM (in 1mL DMSO)
EUR 258
Description: AMD-070 is a selective and oral bioavailable antagonist of chemokine receptor CXCR4 with IC50 value of 13 nM [1].CXCR4 is a G-protein-coupled receptor that plays important roles in tumor development.

AMD-070

A3173-50 50 mg
EUR 1025
Description: AMD-070 is a selective and oral bioavailable antagonist of chemokine receptor CXCR4 with IC50 value of 13 nM [1].CXCR4 is a G-protein-coupled receptor that plays important roles in tumor development.

AMD 3465 (hexahydrobromide)

HY-15971 10mM/1mL
EUR 160

AMD Polyclonal Antibody

ES11246-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against AMD from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

AMD Polyclonal Antibody

ES11246-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against AMD from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-AMD antibody

STJ192404 200 µl
EUR 197
Description: Unconjugated Rabbit polyclonal to AMD

AMD Polyclonal Antibody

ABP57751-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of AMD from Human, Mouse, Rat. This AMD antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AMD protein at amino acid sequence of 380-460

AMD Polyclonal Antibody

ABP57751-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of AMD from Human, Mouse, Rat. This AMD antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AMD protein at amino acid sequence of 380-460

AMD Polyclonal Antibody

ABP57751-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of AMD from Human, Mouse, Rat. This AMD antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AMD protein at amino acid sequence of 380-460

AMD 3465 hexahydrobromide

B3397-10 10 mg
EUR 255
Description: AMD 3465 6HBr(GENZ-644494) is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100; inhibits SDF-1?-ligand binding (Ki = 41.7 nM).

AMD 3465 hexahydrobromide

B3397-25 25 mg
EUR 512
Description: AMD 3465 6HBr(GENZ-644494) is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100; inhibits SDF-1?-ligand binding (Ki = 41.7 nM).

AMD 3465 hexahydrobromide

B3397-5 5 mg
EUR 158
Description: AMD 3465 6HBr(GENZ-644494) is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100; inhibits SDF-1?-ligand binding (Ki = 41.7 nM).

AMD-070 hydrochloride

A3174-10 10 mg
EUR 374
Description: AMD-070(AMD 070), CXCR4 antagonist, is useful for Anti HIV.

AMD-070 hydrochloride

A3174-25 25 mg
EUR 645
Description: AMD-070(AMD 070), CXCR4 antagonist, is useful for Anti HIV.

AMD-070 hydrochloride

A3174-5 5 mg
EUR 235
Description: AMD-070(AMD 070), CXCR4 antagonist, is useful for Anti HIV.

AMD-070 hydrochloride

A3174-50 50 mg
EUR 1025
Description: AMD-070(AMD 070), CXCR4 antagonist, is useful for Anti HIV.

Custom Peptide Synthesis (>95; mass spec, hplc (mg-kg size, price based upon peptide size: 2-100 aa)

PEP-95 1 Ask for price

Polyclonal LPAR1 / LPA1 / EDG2 Antibody (aa5-54)

APR08258G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LPAR1 / LPA1 / EDG2 (aa5-54). This antibody is tested and proven to work in the following applications:

Anserini AMD ELISA Kit

EAA0054 96Tests
EUR 521

HBcAb Sandwich ELISA test

95 96T/Box Ask for price
Description: ELISA based test for quantitative detection of HBcAb Sandwich

pOTENT- CMV- Flag- His- Puro Plasmid

PVT2340 2 ug
EUR 241

pOTENT-CMV-SIRT3-FLAG-His-Puro Plasmid

PVT15866 2 ug
EUR 325

Nobiletin, 95%

GP8719-100MG 100 mg
EUR 94

Stigmasterol, 95%

GP9119-10G 10 g
EUR 118

Stigmasterol, 95%

GP9119-1G 1 g
EUR 50

Stigmasterol, 95%

GP9119-25G 25 g
EUR 198

Stigmasterol, 95%

GP9119-5G 5 g
EUR 78

Epicatechin, 95%

GP4379-25MG 25 mg
EUR 229

Epicatechin, 95%

GP4379-5MG 5 mg
EUR 102

Virginiamycin >95%

V030-100MG 100mg
EUR 269

Virginiamycin >95%

V030-500MG 500mg
EUR 517

miRZip-95 anti-miR-95 microRNA construct

MZIP95-PA-1 Bacterial Streak
EUR 684

Recombinant (E.Coli) Human BAFF receptor (BAFFR) (>95%) active

RP-1626 10 ug
EUR 286

Spinosyn A >95%

S114-100MG 100mg
EUR 303

Spinosyn A >95%

S114-10MG 10mg
EUR 163

Mycoplasma pneumoniae (>95%)

DAGA-502 200ug
EUR 897

Human IgG(>95%)

E61I00801 100mg
EUR 984

Human IgG(>95%)

E61I00802 1g
EUR 3788

Ouabain octahydrate, 95%

GC9310-100MG 100 mg
EUR 85

PSD-95/SAP90

MO50000 100 ul
EUR 579

Methyl linoleate, 95%

GK5973-1G 1 g
EUR 50

Emamectin benzoate, 95%

GP2114-25G 25 g
EUR 86

Dimidium bromide, 95%

GT1911-1G 1 g
EUR 98

Dimidium bromide, 95%

GT1911-250MG 250 mg
EUR 58

Dimidium bromide, 95%

GT1911-5G 5 g
EUR 269

Bafilomycin A1, >95%

BC004-001 1mg
EUR 367

Bafilomycin A1, >95%

BC004-005 5mg
EUR 1373

Bafilomycin A1, >95%

BC004-010 10mg Ask for price

Cupric Bromide,95%

abx188661-25g 25 g
EUR 286

83161-95-9

TBZ1629 unit Ask for price

Hemagglutinin Recombinant Protein

95-101 0.05 mg
EUR 322.25
Description: Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, but it is in birds that all subtypes can be found (2). These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with host cell surface proteins containing oligosaccharides with terminal sialyl residues. Its extracellular region has two domains (HA1 and HA2); HA1 is cleaved from the main hemagglutinin protein by the host immune system. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong (3). This more recent virulent strain of H5N1 is now seen in Africa and Europe, as well as in Southeast Asia. There is some evidence of human to human spread of this virus, but it is thought that the efficiency of this type of transmission is low (4). Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability (5). This HA1 recombinant protein is recognized by several ProSci hemagglutinin antibodies.

PUMA Fragment Recombinant Protein

95-102 0.05 mg
EUR 322.25
Description: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA- and PUMA- (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. This PUMA recombinant protein is recognized by several ProSci PUMA monoclonal antibodies, but not the two polyclonal antibodies (PSI # 3041 and 3043).

EndoG Fragment Recombinant Protein

95-103 0.05 mg
EUR 322.25
Description: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribo-nuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1-3). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndoG also cleaves DNA in vitro (4).

MyD88 Fragment Recombinant Protein

95-104 0.05 mg
EUR 322.25
Description: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

CD4 Fragment Recombinant Protein

95-105 0.05 mg
EUR 322.25
Description: CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response (1). On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120 (2). This soluble CD4 fragment (sCD4) will work in HIV neutralization assays at levels comparable to previously published results. The minor upper band seen in the Coomassie blue-stained gel is likely to be due to the presence of uncleaved signal sequence.

IL-33 Recombinant Protein

95-106 0.05 mg
EUR 322.25
Description: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5).

XBP1 Recombinant Protein

95-109 0.05 mg
EUR 322.25
Description: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) (1). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).

Integrin alpha 4 Recombinant Protein

95-110 0.05 mg
EUR 322.25
Description: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains (reviewed in 1). Alpha 4 (4) chain associates with either beta 1 (1) or beta 77) chain. It has been demonstrated that the putative ligand-binding sites of both integrin 41 and 47 is located on the 4 chain. These ligands included Madcam, VCAM, and fibronectin (2-4). Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin 47, the gut mucosal homing receptor for peripheral T cells (5). This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4 (IN1) (PSI 4827) and Integrin 4 (IN2) (PSI 4837), but not Integrin 4 (CT) (PSI 4783).

IL-33 Recombinant Protein

95-111 0.05 mg
EUR 322.25
Description: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5). This recombinant protein represents the cleaved and presumably activated form of IL-33, but has not been tested in any biological assays.

AMD 95 Potent LPA1 receptor